The Nazis first attacked some professions and positions with high power or social status. Then mixed marriages. Then virtually all professions, property, and normal ways of living. Then they rounded them up. By the time the rounding up was happening, the life was no longer normal for Jews in Germany anymore and hadn't been for years. But it was all a gradual escalation. They would have failed to implement the last stage of the program if they had tried to implement it before the initial stage.

If the Jews had reacted forcefully enough at the initial stages, they could have delayed significantly the application of the latter stages. Whether or not that would have prevented the war itself, it would have saved many more of them. But one of the wrong views held by many German Jews was that either the lunacy was temporary and would die off, or that the anti-Jew measures would stop after this new one and not worsen. Perspective of course is 20/20, but their example shows, if anything, that you cannot pick and choose which issues are important and which aren't. You have to treat all issues as crucial. If for no other reason, because that way you stretch the enemy across too many front lines.