Simpsons, as is the running joke - did it first; Maggie/Moe is canon...
...but South Park is my favorite. The "save the rainforest" episode not only gave us a song, fully epic, but also went with the "fuck antis" in a literally-radical fashion. Epic.
I'll take almost any, but radical "fuck antis" = best "fuck antis." Anti as I am. ;)
Most of the other major animated series have few episodes. And a damn hefty chunk of childrens' cartoons. And several more.
Also, we made it on star trek before the PVF. Just part of hard telling off about mass erasure. ;)